top of page

Cellular Engineering

The Jiang lab combines synthetic biology and AI models to program mammalian cells to understand molecular circuit behind disease and homeostasis. With these knowledge, we develop technology to engineer molecules, cells and multi-celluar systems to address diseases including cancer, autoimmune disorders, and aging

屏幕截图 2025-05-15 151730.png

About Us

Immune cells

We are a dynamic research group based in Princeton University’s Omenn-Darling Bioengineering Institute. As molecular engineers, we integrate high throughput synthetic biology with computational approaches to develop next-generation tools for cellular engineering and therapeutic innovation. Our work involves the development of new technologies and deep learning models that enable programmable control over biomolecules, cells, and multicellular systems. We leverage the diversity of biology to discover modular parts for building synthetic circuits and use these circuits to reprogram cells. These platforms also serve as the foundation for high-throughput functional data collection, which fuels the training of foundation models in therapeutically relevant contexts.

Highlighted Publications

Rapid in silico directed evolution by a protein language model with EVOLVEpro

EVOLVEpro: 

Rapid in silico directed evolution by a protein language model 

Programmable eukaryotic protein synthesis with RNA sensors by harnessing ADAR

RADARS:

Programmable RNA sensor for cell state sensing

RNA triggered protein clevage and cell growth arrest by the type III-E CRISPR nuclease-protease

Cas7-11/Csx29:

RNA-guided protein clevage system

bottom of page